![]() Taipale J, Keski-Oja J (1997) Growth factors in the extracellular matrix. Jain A, Kim Y-T, McKeon RJ, Bellamkonda RV (2006) In situ gelling hydrogels for conformal repair of spinal cord defects, and local delivery of BDNF after spinal cord injury. Yang R, Xu C, Wang T, Wang Y, Wang J, Quan D, Deng DY (2017) PTMAc-PEG-PTMAc hydrogel modified by RGDC and hyaluronic acid promotes neural stem cells’ survival and differentiation in vitro. Gonzalez-Perez F, Cobianchi S, Heimann C, Phillips JB, Udina E, Navarro X (2017) Stabilization, rolling, and addition of other extracellular matrix proteins to collagen hydrogels improve regeneration in chitosan guides for long peripheral nerve gaps in rats. Platt JL, Vercellotti GM, Dalmasso AP, Matas AJ, Bolman RM, Najarian JS, Bach FH (1990) Transplantation of discordant xenografts: a review of progress. Hand Clin 16:105–122Įvans PJ, Midha R, Mackinnon SE (1994) The peripheral nerve allograft: a comprehensive review of regeneration and neuroimmunology. Trumble TE, Shon FG (2000) The physiology of nerve transplantation. Nat Rev Neurosci 4:703–713Īrtico M, Cervoni L, Nucci F, Giuffre R (1996) Birthday of peripheral nervous system surgery: the contribution of Gabriele Ferrara (1543–1627). Exp Neurol 209:294–301įilbin MT (2003) Myelin-associated inhibitors of axonal regeneration in the adult mammalian CNS. Academic Press, pp 1–7įitch MT, Silver J (2008) CNS injury, glial scars, and inflammation: inhibitory extracellular matrices and regeneration failure. Muscle Nerve 23:863–873īattiston B, Papalia I, Tos P, Geuna S (2009) Chapter 1 peripheral nerve repair and regeneration research: a historical note. Robinson LR (2000) Traumatic injury to peripheral nerves. Keywordsīhalala OG, Srikanth M, Kessler JA (2013) The emerging roles of microRNAs in CNS injuries. Finally, the challenges and future potentialities have been addressed. Further, we have discussed the recent advances of electrospun polymeric scaffolds in neural tissue engineering. In this book chapter, we have demonstrated the principal parameters necessary for suitable electrospinning. These produced fibers can be random or oriented to assist the extension of neurite via contact guidance. The electrospun substrates have a high prospective in mimicking the structure of the natural extracellular matrix. Majorly, the electrospinning method has come into the limelight for the fabrication of the scaffolds as they can develop fibrous meshes with fiber diameter in nanoscale dimensions. Lately, tissue engineering methods have enticed many scientists to lead tissue regeneration efficiently. Therefore, a successful therapeutic approach to bring functional rehabilitation is immediately required. The continuing functional loss owing to inadequate regeneration of the nerve is a significant problem around the world. Though the peripheral nerves regenerate to some extent, the consequent findings are not satisfactory, especially for severe injuries. ![]() Furthermore, the existing therapeutic modalities comprising the utilization of conventional grafts and pharmacological actives have numerous shortcomings and cannot completely rehabilitate injuries to the nervous system. The complication of the structure and function of the nervous system, and its slow rate of regeneration, make it further challenging to treat in comparison to other human tissues when damage takes place. The repairing procedure in the nervous system is intricate and brings significant difficulties to investigators. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |